Version 5.4
Bos taurus Protein: BLVRB
Summary
InnateDB Protein IDBP-689961.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BLVRB
Protein Name Flavin reductase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013889
InnateDB Gene IDBG-637927 (BLVRB)
Protein Structure
UniProt Annotation
Function Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity At least expressed in the liver and erythrocyte.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004074 biliverdin reductase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042602 riboflavin reductase (NADPH) activity
GO:0050662 coenzyme binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0042167 heme catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR008030 NmrA-like domain
PFAM PF01370
PF01073
PF05368
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P52556
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281650
UniGene
RefSeq NP_776676
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102269 L35045
GenPept AAC37323 AAI02270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca