InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ROCK2

Summary

InnateDB Protein

IDBP-690057.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROCK2

Protein Name

rho-associated protein kinase 2

Synonyms

ROCK-II;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007691

InnateDB Gene

IDBG-638012 (ROCK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001843	neural tube closure
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010825	positive regulation of centrosome duplication
GO:0016310	phosphorylation
GO:0016525	negative regulation of angiogenesis
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0045616	regulation of keratinocyte differentiation
GO:0051298	centrosome duplication

Cellular Component

GO:0005813	centrosome
GO:0031616	spindle pole centrosome
GO:0036464	cytoplasmic ribonucleoprotein granule

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010978 tRNA-binding arm
IPR011009 Protein kinase-like domain
IPR015008 Rho binding domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020684 Rho-associated protein kinase 1/2

PFAM

PF00069
PF07714
PF00169
PF00130
PF08912
PF00433

PRINTS

PR00109

PIRSF

PIRSF037568

SMART

SM00133
SM00233
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1N319

UniProt Splice Variant

Entrez Gene

282041

UniGene

Bt.120

RefSeq

NP_776877

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02031908 DAAA02031909

GenPept