InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: COMT

Summary

InnateDB Protein

IDBP-690206.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COMT

Protein Name

Catechol O-methyltransferase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025997

InnateDB Gene

IDBG-638156 (COMT)

Protein Structure

UniProt Annotation

Function

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 2: Cytoplasm {ECO:0000250}.Isoform 1: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0016206	catechol O-methyltransferase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006584	catecholamine metabolic process
GO:0009712	catechol-containing compound metabolic process
GO:0016036	cellular response to phosphate starvation
GO:0032259	methylation
GO:0042135	neurotransmitter catabolic process
GO:0042417	dopamine metabolic process
GO:0042420	dopamine catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome