InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: INSIG1

Summary

InnateDB Protein

IDBP-690265.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INSIG1

Protein Name

Insulin-induced gene 1 protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002084

InnateDB Gene

IDBG-638211 (INSIG1)

Protein Structure

UniProt Annotation

Function

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0006991	response to sterol depletion
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0010894	negative regulation of steroid biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0032933	SREBP signaling pathway
GO:0042472	inner ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0045599	negative regulation of fat cell differentiation
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0060021	palate development
GO:0060363	cranial suture morphogenesis
GO:1901303	negative regulation of cargo loading into COPII-coated vesicle

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032937	SREBP-SCAP-Insig complex