InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATR

Summary

InnateDB Protein

IDBP-690270.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATR

Protein Name

ataxia telangiectasia and Rad3 related

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015321

InnateDB Gene

IDBG-638174 (ATR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.

Predicted by orthology
Total	89 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0032405	MutLalpha complex binding
GO:0032407	MutSalpha complex binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0008156	negative regulation of DNA replication
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0034644	cellular response to UV
GO:0043393	regulation of protein binding
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	protein autophosphorylation
GO:0071480	cellular response to gamma radiation
GO:0090399	replicative senescence

Cellular Component

GO:0001741	XY body
GO:0016605	PML body

Protein Structure and Domains

PDB ID

InterPro

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151 PIK-related kinase, FAT
IPR003152 PIK-related kinase, FATC
IPR011009 Protein kinase-like domain
IPR012993 UME
IPR014009 PIK-related kinase
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2

PFAM

PF00454
PF02259
PF02260
PF08064

PRINTS

PIRSF

SMART

SM00146
SM00802

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite