InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SNRPA

Summary

InnateDB Protein

IDBP-690285.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRPA

Protein Name

U1 small nuclear ribonucleoprotein A

Synonyms

U1A;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011963

InnateDB Gene

IDBG-638228 (SNRPA)

Protein Structure

UniProt Annotation

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0017069	snRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005685	U1 snRNP
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KIR1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

509802

UniGene

Bt.92011

RefSeq

NP_001039504

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC112544

GenPept

AAI12545