InnateDB Protein
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IDBP-690402.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLD6
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Protein Name
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Mitochondrial cardiolipin hydrolase
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Synonyms
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mitoPLD;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000010531
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InnateDB Gene
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IDBG-638345 (PLD6)
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Protein Structure
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Function |
Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low. In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001736
Phospholipase D/Transphosphatidylase
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PFAM |
PF00614
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PRINTS |
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PIRSF |
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SMART |
SM00155
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TIGRFAMs |
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Modification |
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SwissProt |
E1BE10
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
526651
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UniGene |
Bt.88339
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RefSeq |
NP_001258919
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AAFC03031113
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GenPept |
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