InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ALAD

Summary

InnateDB Protein

IDBP-690414.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALAD

Protein Name

Delta-aminolevulinic acid dehydratase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000315

InnateDB Gene

IDBG-638350 (ALAD)

Protein Structure

UniProt Annotation

Function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004655	porphobilinogen synthase activity
GO:0008270	zinc ion binding
GO:0016829	lyase activity
GO:0032791	lead ion binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008152	metabolic process
GO:0033014	tetrapyrrole biosynthetic process
GO:0051260	protein homooligomerization
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001731 Porphobilinogen synthase

PFAM

PF00490

PRINTS

PR00144

PIRSF

PIRSF001415

SMART

SM01004

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58DK5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

510679

UniGene

Bt.37574

RefSeq

NP_001014895

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT021592

GenPept

AAX46439