Version 5.4
Bos taurus Protein: ADAM17
Summary
InnateDB Protein IDBP-690425.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM17
Protein Name ADAM metallopeptidase domain 17
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000054909
InnateDB Gene IDBG-638333 (ADAM17)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005112 Notch binding
GO:0005138 interleukin-6 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0030165 PDZ domain binding
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002467 germinal center formation
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007220 Notch receptor processing
GO:0008284 positive regulation of cell proliferation
GO:0010820 positive regulation of T cell chemotaxis
GO:0030183 B cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032496 response to lipopolysaccharide
GO:0032717 negative regulation of interleukin-8 production
GO:0032722 positive regulation of chemokine production
GO:0033025 regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033627 cell adhesion mediated by integrin
GO:0035313 wound healing, spreading of epidermal cells
GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042493 response to drug
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0048536 spleen development
GO:0048870 cell motility
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis
GO:0051272 positive regulation of cellular component movement
GO:0055099 response to high density lipoprotein particle stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0032587 ruffle membrane
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
PFAM PF01421
PF00200
PF01562
PRINTS PR00289
PIRSF
SMART SM00050
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3MZB3
UniProt Splice Variant
Entrez Gene 517541
UniGene
RefSeq
HUGO HGNC:195
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02031941
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca