Bos taurus Protein: EIF2S3 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-690473.2 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | EIF2S3 | ||||||||||||
Protein Name | Eukaryotic translation initiation factor 2 subunit 3 | ||||||||||||
Synonyms | |||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Protein | ENSBTAP00000019064 | ||||||||||||
InnateDB Gene | IDBG-638406 (EIF2S3) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | |||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | |||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR000795
Elongation factor, GTP-binding domain IPR004161 Translation elongation factor EFTu/EF1A, domain 2 IPR009000 Translation protein, beta-barrel domain IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal IPR015256 Translation initiation factor 2, gamma subunit, C-terminal IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00009
PF03144 PF09173 |
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PRINTS |
PR00315
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PIRSF | |||||||||||||
SMART | |||||||||||||
TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q2KHU8 | ||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 512350 | ||||||||||||
UniGene | Bt.21351 | ||||||||||||
RefSeq | NP_001039582 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | BC112875 BT030491 | ||||||||||||
GenPept | AAI12876 ABQ12931 | ||||||||||||