Version 5.4
Bos taurus Protein: PRDX4
Summary
InnateDB Protein IDBP-690504.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDX4
Protein Name Peroxiredoxin-4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008107
InnateDB Gene IDBG-638437 (PRDX4)
Protein Structure
UniProt Annotation
Function Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0051920 peroxiredoxin activity
Biological Process
GO:0007283 spermatogenesis
GO:0008584 male gonad development
GO:0019471 4-hydroxyproline metabolic process
GO:0022417 protein maturation by protein folding
GO:0030198 extracellular matrix organization
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
GO:2000255 negative regulation of male germ cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin
IPR019479 Peroxiredoxin, C-terminal
PFAM PF00578
PF13098
PF13192
PF13462
PF13905
PF08534
PF10417
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BGI2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281999
UniGene
RefSeq NP_776858
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF305563 BC109824
GenPept AAG53660 AAI09825

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca