Version 5.4
Bos taurus Protein: JAK1
Summary
InnateDB Protein IDBP-690532.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JAK1
Protein Name Tyrosine-protein kinase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004101
InnateDB Gene IDBG-638346 (JAK1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Predicted by orthology
Total 69 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0038110 interleukin-2-mediated signaling pathway
GO:0046677 response to antibiotic
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020776 Tyrosine-protein kinase, non-receptor Jak1
PFAM PF00069
PF00017
PF14633
PF07714
PF00373
PRINTS PR00401
PR00109
PR01823
PR01824
PIRSF PIRSF000636
SMART SM00252
SM00220
SM00295
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1N0D6
UniProt Splice Variant
Entrez Gene 537201
UniGene Bt.67031
RefSeq NP_001193463
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133420 DAAA02008528
GenPept AAI33421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca