Version 5.4
Bos taurus Protein: ZFYVE27
Summary
InnateDB Protein IDBP-690540.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE27
Protein Name Protrudin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024705
InnateDB Gene IDBG-638470 (ZFYVE27)
Protein Structure
UniProt Annotation
Function Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation (By similarity). {ECO:0000250}.
Subcellular Localization Recycling endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, growth cone membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes at both dendrites and axons. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0031175 neuron projection development
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032584 growth cone membrane
GO:0042995 cell projection
GO:0055038 recycling endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR000306 FYVE zinc finger
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PRINTS
PIRSF
SMART SM00064
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5BIM5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514383
UniGene Bt.54620
RefSeq NP_001017939
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134516 BT021199
GenPept AAI34517 AAX31381

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca