Bos taurus Protein: LRRC59
Summary
InnateDB Protein IDBP-690657.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC59
Protein Name Leucine-rich repeat-containing protein 59
Synonyms PRO1855;
Species Bos taurus
Ensembl Protein ENSBTAP00000007978
InnateDB Gene IDBG-638585 (LRRC59)
Protein Structure
UniProt Annotation
Function Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity). {ECO:0000250}.
Subcellular Localization Microsome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031090 organelle membrane
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9X4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 532659
UniGene Bt.24660
RefSeq NP_001029750
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118231 BT020796
GenPept AAI18232 AAX08813