InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: COL1A1

Summary

InnateDB Protein

IDBP-690737.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL1A1

Protein Name

Collagen alpha-1(I) chain

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017420

InnateDB Gene

IDBG-638637 (COL1A1)

Protein Structure

UniProt Annotation

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000255PROSITE-ProRule:PRU00793}.

Disease Associations

Tissue Specificity

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001501	skeletal system development
GO:0001568	blood vessel development
GO:0001649	osteoblast differentiation
GO:0001957	intramembranous ossification
GO:0001958	endochondral ossification
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010812	negative regulation of cell-substrate adhesion
GO:0015031	protein transport
GO:0030199	collagen fibril organization
GO:0030335	positive regulation of cell migration
GO:0032964	collagen biosynthetic process
GO:0034504	protein localization to nucleus
GO:0034505	tooth mineralization
GO:0043588	skin development
GO:0043589	skin morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048705	skeletal system morphogenesis
GO:0048706	embryonic skeletal system development
GO:0060325	face morphogenesis
GO:0060346	bone trabecula formation
GO:0060351	cartilage development involved in endochondral bone morphogenesis
GO:0070208	protein heterotrimerization
GO:0071230	cellular response to amino acid stimulus
GO:0071260	cellular response to mechanical stimulus
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005584	collagen type I
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000885 Fibrillar collagen, C-terminal
IPR001007 von Willebrand factor, type C
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160 Collagen triple helix repeat

PFAM

PF01410
PF00093
PF00147
PF01391

PRINTS

PIRSF

SMART

SM00038
SM00214
SM00186

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P02453