Version 5.4
Bos taurus Protein: DSTN
Summary
InnateDB Protein IDBP-690807.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSTN
Protein Name Destrin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020512
InnateDB Gene IDBG-638717 (DSTN)
Protein Structure
UniProt Annotation
Function Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0000910 cytokinesis
GO:0006928 cellular component movement
GO:0030042 actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002108 Actin-depolymerising factor homology domain
IPR017904 ADF/Cofilin/Destrin
PFAM PF00241
PRINTS PR00006
PIRSF
SMART SM00102
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9D5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 513267
UniGene
RefSeq NP_001015586
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103074 BT020985
GenPept AAI03075 AAX09002

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca