InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EPHB1

Summary

InnateDB Protein

IDBP-690838.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHB1

Protein Name

EPH receptor B1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020455

InnateDB Gene

IDBG-638744 (EPHB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021545	cranial nerve development
GO:0021631	optic nerve morphogenesis
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022008	neurogenesis
GO:0030010	establishment of cell polarity
GO:0031290	retinal ganglion cell axon guidance
GO:0031589	cell-substrate adhesion
GO:0046328	regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048593	camera-type eye morphogenesis
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051965	positive regulation of synapse assembly
GO:0060326	cell chemotaxis
GO:0060996	dendritic spine development
GO:0060997	dendritic spine morphogenesis
GO:0061351	neural precursor cell proliferation
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0031901	early endosome membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF00069
PF01404
PF07714
PF00041
PF01108
PF07647
PF00536

PRINTS

PR00109

PIRSF

PIRSF000666

SMART

SM00615
SM00454
SM00220
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1MII5

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

HGNC:3392

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02003029 DAAA02003030 DAAA02003031 DAAA02003032 DAAA02003033 DAAA02003034

GenPept