InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: KRAS

Summary

InnateDB Protein

IDBP-690881.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRAS

Protein Name

GTPase KRas

Synonyms

KRAS2; p21ras;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000040751

InnateDB Gene

IDBG-638783 (KRAS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0032403	protein complex binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0008542	visual learning
GO:0010628	positive regulation of gene expression
GO:0015031	protein transport
GO:0030036	actin cytoskeleton organization
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0035022	positive regulation of Rac protein signal transduction
GO:0043524	negative regulation of neuron apoptotic process
GO:0045596	negative regulation of cell differentiation
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0051146	striated muscle cell differentiation
GO:0060441	epithelial tube branching involved in lung morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt