InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CTPS2

Summary

InnateDB Protein

IDBP-690949.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTPS2

Protein Name

CTP synthase 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022629

InnateDB Gene

IDBG-638838 (CTPS2)

Protein Structure

UniProt Annotation

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016874	ligase activity

Biological Process

GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006541	glutamine metabolic process
GO:0044210	'de novo' CTP biosynthetic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR004468 CTP synthase
IPR011697 Peptidase C26
IPR017456 CTP synthase, N-terminal
IPR017926 Glutamine amidotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029062 Class I glutamine amidotransferase-like

PFAM

PF07722
PF06418
PF00117

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1RMS2

PhosphoSite