Version 5.4
Bos taurus Protein: CD79A
Summary
InnateDB Protein IDBP-691039.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD79A
Protein Name B-cell antigen receptor complex-associated protein alpha chain
Synonyms MB-1;
Species Bos taurus
Ensembl Protein ENSBTAP00000031933
InnateDB Gene IDBG-638925 (CD79A)
Protein Structure
UniProt Annotation
Function Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
Disease Associations
Tissue Specificity B-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0007166 cell surface receptor signaling pathway
GO:0030183 B cell differentiation
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005771 multivesicular body
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019815 B cell receptor complex
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF07679
PF07686
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P40293
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281674
UniGene Bt.4436
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120260 D16412 D16459
GenPept AAI20261 BAA03899 BAA03926

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca