InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: C5H12orf39

Summary

InnateDB Protein

IDBP-691077.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C5H12orf39

Protein Name

Spexin

Synonyms

C5H12orf39; NPQ;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000491

InnateDB Gene

IDBG-638967 (C5H12orf39)

Protein Structure

UniProt Annotation

Function

Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). {ECO:0000250}.Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic- like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes. Acts as a ligand for galanin receptors GALR2 and GALR3 (By similarity). {ECO:0000250}.Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}. Secreted, extracellular space {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Secreted via the classical ER/Golgi- dependent pathway into the extracellular medium largely as a full- length protein without the signal peptide, and not as a hydrolyzed and amidated peptide. Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005184	neuropeptide hormone activity
GO:0031765	type 2 galanin receptor binding
GO:0031766	type 3 galanin receptor binding

Biological Process

GO:0003084	positive regulation of systemic arterial blood pressure
GO:0010459	negative regulation of heart rate
GO:0032099	negative regulation of appetite
GO:0035814	negative regulation of renal sodium excretion
GO:0044539	long-chain fatty acid import
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051930	regulation of sensory perception of pain

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0030133	transport vesicle
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VC44

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

509493

UniGene

Bt.17644

RefSeq

NP_001068875

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120360

GenPept

AAI20361