Version 5.4
Bos taurus Protein: AK1
Summary
InnateDB Protein IDBP-691181.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AK1
Protein Name Adenylate kinase isoenzyme 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000050234
InnateDB Gene IDBG-639064 (AK1)
Protein Structure
UniProt Annotation
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000255HAMAP-Rule:MF_03171}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004017 adenylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019205 nucleobase-containing compound kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006172 ADP biosynthetic process
GO:0007050 cell cycle arrest
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0046033 AMP metabolic process
GO:0046034 ATP metabolic process
Cellular Component
GO:0001520 outer dense fiber
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0036126 sperm flagellum
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006267 Adenylate kinase, isozyme 1/5
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS PR00094
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00570
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280715
UniGene Bt.4224
RefSeq NP_001013600
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114796 BT020951
GenPept AAI14797 AAX08968

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca