InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SULT1A1

Summary

InnateDB Protein

IDBP-691273.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1A1

Protein Name

Sulfotransferase 1A1

Synonyms

ST1A1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011388

InnateDB Gene

IDBG-639134 (SULT1A1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Distal lung parenchyma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004062	aryl sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0016740	transferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0006629	lipid metabolic process
GO:0008202	steroid metabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00685

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50227

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282485

UniGene

RefSeq

XP_005224892

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102274 L33828 U34753 U35253

GenPept

AAA56789 AAA85510 AAC48677 AAI02275