Version 5.4
| Bos taurus Protein: LASP1 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Protein | IDBP-691395.2 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | LASP1 | ||||||||||||
| Protein Name | LIM and SH3 domain protein 1 | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Protein | ENSBTAP00000040793 | ||||||||||||
| InnateDB Gene | IDBG-639256 (LASP1) | ||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||
| Function | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. | ||||||||||||
| Subcellular Localization | Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the F- actin rich cortical cytoskeleton. {ECO:0000250}. | ||||||||||||
| Disease Associations | |||||||||||||
| Tissue Specificity | |||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||
| PDB ID | |||||||||||||
| InterPro |
IPR000900
Nebulin repeat IPR001452 SH3 domain IPR001781 Zinc finger, LIM-type IPR011511 Variant SH3 domain |
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| PFAM |
PF00880
PF00018 PF14604 PF00412 PF07653 |
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| PRINTS |
PR00452
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| PIRSF | |||||||||||||
| SMART |
SM00227
SM00326 SM00132 |
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| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q3B7M5 | ||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 787753 | ||||||||||||
| UniGene | Bt.7980 | ||||||||||||
| RefSeq | NP_001030471 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC107542 | ||||||||||||
| GenPept | AAI07543 | ||||||||||||