InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ORC1

Summary

InnateDB Protein

IDBP-691516.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ORC1

Protein Name

origin recognition complex subunit 1

Synonyms

ORC1L;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000048350

InnateDB Gene

IDBG-639359 (ORC1)

Protein Structure

UniProt Annotation

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006260

DNA replication

Cellular Component

GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex

Protein Structure and Domains

PDB ID

InterPro

IPR001025 Bromo adjacent homology (BAH) domain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR015163 CDC6, C-terminal domain
IPR018647 Domain of unknown function DUF2075
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01426
PF00004
PF07724
PF13304
PF09079
PF09848

PRINTS

PIRSF

SMART

SM00439
SM00382
SM01074

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58DC8