Version 5.4
Bos taurus Protein: CDKN1B
Summary
InnateDB Protein IDBP-691569.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDKN1B
Protein Name cyclin-dependent kinase inhibitor 1B
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024297
InnateDB Gene IDBG-639416 (CDKN1B)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.
Predicted by orthology
Total 91 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019903 protein phosphatase binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006813 potassium ion transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007050 cell cycle arrest
GO:0007605 sensory perception of sound
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010942 positive regulation of cell death
GO:0030308 negative regulation of cell growth
GO:0031116 positive regulation of microtubule polymerization
GO:0033673 negative regulation of kinase activity
GO:0042326 negative regulation of phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0048102 autophagic cell death
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051271 negative regulation of cellular component movement
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071236 cellular response to antibiotic
GO:0071285 cellular response to lithium ion
GO:0071407 cellular response to organic cyclic compound
GO:0071850 mitotic cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003175 Cyclin-dependent kinase inhibitor
PFAM PF02234
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6QLS3
UniProt Splice Variant
Entrez Gene 512613
UniGene Bt.99836
RefSeq NP_001093816
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148067 DAAA02014288
GenPept AAI48068

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca