Version 5.4
Bos taurus Protein: CRYAA
Summary
InnateDB Protein IDBP-691779.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRYAA
Protein Name Alpha-crystallin A chainAlpha-crystallin A chain, short form
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004073
InnateDB Gene IDBG-639603 (CRYAA)
Protein Structure
UniProt Annotation
Function Contributes to the transparency and refractive index of the lens (By similarity). Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. {ECO:0000250, ECO:0000269PubMed:20440841}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002088 lens development in camera-type eye
GO:0002089 lens morphogenesis in camera-type eye
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization
GO:0007015 actin filament organization
GO:0007017 microtubule-based process
GO:0007021 tubulin complex assembly
GO:0010629 negative regulation of gene expression
GO:0030307 positive regulation of cell growth
GO:0042542 response to hydrogen peroxide
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048596 embryonic camera-type eye morphogenesis
GO:0060561 apoptotic process involved in morphogenesis
GO:0070141 response to UV-A
GO:0070309 lens fiber cell morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR003090 Alpha-crystallin, N-terminal
IPR008978 HSP20-like chaperone
PFAM PF00011
PF00525
PRINTS PR00299
PIRSF PIRSF036514
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02470
PhosphoSite PhosphoSite-P02470
TrEMBL
UniProt Splice Variant
Entrez Gene 281718
UniGene Bt.397
RefSeq NP_776714
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL M26142
GenPept AAA30471

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca