InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ITGB2

Summary

InnateDB Protein

IDBP-691797.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB2

Protein Name

Integrin beta-2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022687

InnateDB Gene

IDBG-639611 (ITGB2)

Protein Structure

UniProt Annotation

Function

Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (By similarity). Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Note=Defects in ITGB2 are the cause of leukocyte adhesion deficiency (LAD). The mutation causing LAD (Gly-128) is prevalent among Holstein cattle throughout the world, placing this disorder among the most common genetic diseases known in animal agriculture. All cattle with the mutant allele are related to one bull, who through the use of artificial insemination sired many calves in the 1950s and 1960s.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0030593	neutrophil chemotaxis
GO:0050730	regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0008305	integrin complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References