InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RARA

Summary

InnateDB Protein

IDBP-691833.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RARA

Protein Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016586

InnateDB Gene

IDBG-639652 (RARA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 165 interaction(s) predicted by orthology.

Predicted by orthology
Total	165 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001012	RNA polymerase II regulatory region DNA binding
GO:0001972	retinoic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003708	retinoic acid receptor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0031490	chromatin DNA binding
GO:0043422	protein kinase B binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044323	retinoic acid-responsive element binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051018	protein kinase A binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001657	ureteric bud development
GO:0001843	neural tube closure
GO:0002068	glandular epithelial cell development
GO:0003148	outflow tract septum morphogenesis
GO:0003417	growth plate cartilage development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0030852	regulation of granulocyte differentiation
GO:0030853	negative regulation of granulocyte differentiation
GO:0031076	embryonic camera-type eye development
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032689	negative regulation of interferon-gamma production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032736	positive regulation of interleukin-13 production
GO:0032753	positive regulation of interleukin-4 production
GO:0032754	positive regulation of interleukin-5 production
GO:0035264	multicellular organism growth
GO:0043066	negative regulation of apoptotic process
GO:0043277	apoptotic cell clearance
GO:0043401	steroid hormone mediated signaling pathway
GO:0045596	negative regulation of cell differentiation
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045947	negative regulation of translational initiation
GO:0048384	retinoic acid receptor signaling pathway
GO:0051099	positive regulation of binding
GO:0055012	ventricular cardiac muscle cell differentiation
GO:0060010	Sertoli cell fate commitment
GO:0060173	limb development
GO:0060324	face development
GO:0060348	bone development
GO:0060534	trachea cartilage development
GO:0060591	chondroblast differentiation
GO:0061037	negative regulation of cartilage development
GO:0071222	cellular response to lipopolysaccharide
GO:0071300	cellular response to retinoic acid
GO:0071391	cellular response to estrogen stimulus

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00545
PR00047
PR00398
PR01284
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt