Version 5.4
Bos taurus Protein: M6PR
Summary
InnateDB Protein IDBP-691880.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol M6PR
Protein Name Cation-dependent mannose-6-phosphate receptor
Synonyms CD-MPR; CDMPR;
Species Bos taurus
Ensembl Protein ENSBTAP00000024233
InnateDB Gene IDBG-639695 (M6PR)
Protein Structure
UniProt Annotation
Function Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:7559753}; Single-pass type I membrane protein {ECO:0000269PubMed:7559753}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
GO:0015578 mannose transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0015761 mannose transport
Cellular Component
GO:0000323 lytic vacuole
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000296 Cation-dependent mannose-6-phosphate receptor
IPR009011 Mannose-6-phosphate receptor binding domain
IPR028927 Mannose-6-phosphate receptor
PFAM PF02157
PRINTS PR00715
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P11456
PhosphoSite PhosphoSite-P11456
TrEMBL
UniProt Splice Variant
Entrez Gene 281291
UniGene Bt.5032
RefSeq NP_786973
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120081 BT029887 M17025
GenPept AAA30634 AAI20082 ABM06137

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca