Version 5.4
Bos taurus Protein: CCNA2
Summary
InnateDB Protein IDBP-691928.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNA2
Protein Name Cyclin-A2
Synonyms CCNA;
Species Bos taurus
Ensembl Protein ENSBTAP00000006503
InnateDB Gene IDBG-639741 (CCNA2)
Protein Structure
UniProt Annotation
Function Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
Subcellular Localization Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 77 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0007265 Ras protein signal transduction
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR004367 Cyclin, C-terminal domain
IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
IPR014400 Cyclin A/B/D/E/F
PFAM PF02984
PF00134
PRINTS
PIRSF PIRSF001771
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30274
PhosphoSite PhosphoSite-
TrEMBL G8JKW1
UniProt Splice Variant
Entrez Gene 281667
UniGene Bt.87491
RefSeq NP_001068591
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118203 DAAA02015230 X68321
GenPept AAI18204 CAA48398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca