InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CRCP

Summary

InnateDB Protein

IDBP-691954.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRCP

Protein Name

DNA-directed RNA polymerase III subunit RPC9

Synonyms

RCP9;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000048749

InnateDB Gene

IDBG-639764 (CRCP)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa- B through the RIG-I pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001635	calcitonin gene-related polypeptide receptor activity
GO:0003824	catalytic activity
GO:0003899	DNA-directed RNA polymerase activity

Biological Process

GO:0002376	immune system process
GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0007218	neuropeptide signaling pathway
GO:0044237	cellular metabolic process
GO:0045087	innate immune response
GO:0051607	defense response to virus

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0009360	DNA polymerase III complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR005574 RNA polymerase II, Rpb4
IPR006590 RNA polymerase II, Rpb4, core
IPR010997 HRDC-like

PFAM

PF03874

PRINTS

PIRSF

SMART

SM00657

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A0JN61

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

782175

UniGene

Bt.89012

RefSeq

NP_001071338

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC126530

GenPept

AAI26531