Version 5.4
Bos taurus Protein: TCFL2
Summary
InnateDB Protein IDBP-692060.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCFL2
Protein Name transcription factor 7-like 2
Synonyms TCFL2;
Species Bos taurus
Ensembl Protein ENSBTAP00000054093
InnateDB Gene IDBG-639856 (TCFL2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0035257 nuclear hormone receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0005977 glycogen metabolic process
GO:0006006 glucose metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007050 cell cycle arrest
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0009267 cellular response to starvation
GO:0009791 post-embryonic development
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014003 oligodendrocyte development
GO:0016055 Wnt signaling pathway
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030282 bone mineralization
GO:0030514 negative regulation of BMP signaling pathway
GO:0030538 embryonic genitalia morphogenesis
GO:0031641 regulation of myelination
GO:0032024 positive regulation of insulin secretion
GO:0032092 positive regulation of protein binding
GO:0032252 secretory granule localization
GO:0032350 regulation of hormone metabolic process
GO:0035019 somatic stem cell maintenance
GO:0035264 multicellular organism growth
GO:0035411 catenin import into nucleus
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043570 maintenance of DNA repeat elements
GO:0043588 skin development
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0045444 fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046621 negative regulation of organ growth
GO:0046827 positive regulation of protein export from nucleus
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048557 embryonic digestive tract morphogenesis
GO:0048619 embryonic hindgut morphogenesis
GO:0048625 myoblast fate commitment
GO:0048641 regulation of skeletal muscle tissue development
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048699 generation of neurons
GO:0048713 regulation of oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901142 insulin metabolic process
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex
GO:0070369 beta-catenin-TCF7L2 complex
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
IPR013558 CTNNB1 binding, N-teminal
PFAM PF00505
PF09011
PF08347
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3MX34
UniProt Splice Variant
Entrez Gene 540481
UniGene
RefSeq NP_001137211
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02059239 DAAA02059240 DAAA02059241 DAAA02059242 DAAA02059243
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca