Version 5.4
Bos taurus Protein: CHGB
Summary
InnateDB Protein IDBP-692081.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHGB
Protein Name secretogranin-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015645
InnateDB Gene IDBG-639881 (CHGB)
Protein Structure
UniProt Annotation
Function Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites.Secretolytin has antibacterial activity.
Subcellular Localization Secretogranin-1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Lumenal side. Note=Neuroendocrine and endocrine secretory granules. Found to be membrane bound inside the secretory vesicles. The N-terminal region exhibits pH-dependent membrane-binding activity, binds to the membrane at intravesicular pH (5.5) and freed when the pH is near to physiological pH.Peptide BAM-1745: Secreted.Secretolytin: Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR001819 Chromogranin A/B
IPR001990 Chromogranin/secretogranin
PFAM PF01271
PRINTS PR00659
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23389
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281071
UniGene Bt.5448
RefSeq NP_851349
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U88551 X55027 X55489
GenPept AAC48720 CAA38846 CAA39109

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca