InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRKD2

Summary

InnateDB Protein

IDBP-692088.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKD2

Protein Name

protein kinase D2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020721

InnateDB Gene

IDBG-639857 (PRKD2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006468	protein phosphorylation
GO:0008219	cell death
GO:0010595	positive regulation of endothelial cell migration
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032743	positive regulation of interleukin-2 production
GO:0032757	positive regulation of interleukin-8 production
GO:0032793	positive regulation of CREB transcription factor activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050852	T cell receptor signaling pathway
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:1901727	positive regulation of histone deacetylase activity
GO:1902533	positive regulation of intracellular signal transduction
GO:2000573	positive regulation of DNA biosynthetic process
GO:2001028	positive regulation of endothelial cell chemotaxis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00169
PF00130

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00233
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt