Version 5.4
Bos taurus Protein: BMP2
Summary
InnateDB Protein IDBP-692136.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP2
Protein Name bone morphogenetic protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006739
InnateDB Gene IDBG-639937 (BMP2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004745 retinol dehydrogenase activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0019211 phosphatase activator activity
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0070700 BMP receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000187 activation of MAPK activity
GO:0001649 osteoblast differentiation
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001837 epithelial to mesenchymal transition
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002062 chondrocyte differentiation
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003181 atrioventricular valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003308 negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0006029 proteoglycan metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894 negative regulation of steroid biosynthetic process
GO:0010922 positive regulation of phosphatase activity
GO:0021537 telencephalon development
GO:0021978 telencephalon regionalization
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030282 bone mineralization
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0031648 protein destabilization
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0033690 positive regulation of osteoblast proliferation
GO:0035051 cardiac cell differentiation
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0035630 bone mineralization involved in bone maturation
GO:0040007 growth
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042482 positive regulation of odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0043065 positive regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045165 cell fate commitment
GO:0045597 positive regulation of cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048711 positive regulation of astrocyte differentiation
GO:0048762 mesenchymal cell differentiation
GO:0048839 inner ear development
GO:0051042 negative regulation of calcium-independent cell-cell adhesion
GO:0055007 cardiac muscle cell differentiation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055114 oxidation-reduction process
GO:0060039 pericardium development
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060485 mesenchyme development
GO:0060804 positive regulation of Wnt receptor signaling pathway by BMP signaling pathway
GO:0061036 positive regulation of cartilage development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071773 cellular response to BMP stimulus
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900745 positive regulation of p38MAPK cascade
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:2000065 negative regulation of cortisol biosynthetic process
GO:2000726 negative regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine
PFAM PF00688
PF00019
PRINTS PR00669
PIRSF
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A7L634
UniProt Splice Variant
Entrez Gene 615037
UniGene
RefSeq NP_001092611
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134682 BC142129 DAAA02036083 EF673277
GenPept AAI34683 AAI42130 ABS52636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca