InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP1

Summary

InnateDB Protein

IDBP-69223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP1

Protein Name

matrix metallopeptidase 1 (interstitial collagenase)

Synonyms

CLG; CLGN;

Species

Homo sapiens

Ensembl Protein

ENSP00000322788

InnateDB Gene

IDBG-69221 (MMP1)

Protein Structure

UniProt Annotation

Function

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. {ECO:0000269PubMed:1645757}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305PubMed:2167156}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	19 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0016032	viral process
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0044267	cellular protein metabolic process
GO:0050900	leukocyte migration

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References