InnateDB Protein
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IDBP-692437.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRKRA
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Protein Name
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Interferon-inducible double stranded RNA-dependent protein kinase activator A
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Synonyms
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PACT;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000001451
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InnateDB Gene
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IDBG-640208 (PRKRA)
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Protein Structure
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Function |
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
29 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR014720
Double-stranded RNA-binding domain
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PFAM |
PF00035
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PRINTS |
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PIRSF |
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SMART |
SM00358
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TIGRFAMs |
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Modification |
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SwissProt |
Q2HJ92
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q9BDI6
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UniProt Splice Variant |
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Entrez Gene |
282875
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UniGene |
Bt.13570
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RefSeq |
NP_001039335
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF356349
BC113246
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GenPept |
AAI13247
AAK26436
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