InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IDH3B

Summary

InnateDB Protein

IDBP-692537.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDH3B

Protein Name

Isocitrate dehydrogenase

Synonyms

IDH1; IDH3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025044

InnateDB Gene

IDBG-640289 (IDH3B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Isoform A is predominant in heart muscle; also found in brain, kidney and liver. Isoform B is present in kidney and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004449	isocitrate dehydrogenase (NAD+) activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872	metal ion binding
GO:0051287	NAD binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR004434 Isocitrate dehydrogenase NAD-dependent
IPR024084 Isopropylmalate dehydrogenase-like domain

PFAM

PF00180

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O77784

PhosphoSite

PhosphoSite-

TrEMBL

Q9BGH9

UniProt Splice Variant

Entrez Gene

613338

UniGene

Bt.56156

RefSeq

NP_001161346

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF090321 AF090322 AF307303 BC104502

GenPept

AAC83166 AAC83167 AAG49483 AAI04503