InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SNRNP70

Summary

InnateDB Protein

IDBP-692648.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRNP70

Protein Name

U1 small nuclear ribonucleoprotein 70 kDa

Synonyms

SNRP70;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002587

InnateDB Gene

IDBG-640390 (SNRNP70)

Protein Structure

UniProt Annotation

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.

Predicted by orthology
Total	85 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0043484	regulation of RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005685	U1 snRNP
GO:0016607	nuclear speck
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR022023 U1 small nuclear ribonucleoprotein of 70kDa N-terminal

PFAM

PF00076
PF12220

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1RMR2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

535113

UniGene

Bt.12748

RefSeq

NP_001069514

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114762

GenPept

AAI14763