InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MCMBP

Summary

InnateDB Protein

IDBP-692664.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCMBP

Protein Name

Mini-chromosome maintenance complex-binding protein

Synonyms

C26H10ORF119; MCM-BP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013028

InnateDB Gene

IDBG-640400 (MCMBP)

Protein Structure

UniProt Annotation

Function

Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0000084	mitotic S phase
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0007049	cell cycle
GO:0007062	sister chromatid cohesion
GO:0007067	mitotic nuclear division
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0042555	MCM complex

Protein Structure and Domains

PDB ID

InterPro

IPR019140 Mini-chromosome maintenance complex-binding protein

PFAM

PF09739

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5PJM5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

514863

UniGene

Bt.96261

RefSeq

NP_001092444

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC142172

GenPept

AAI42173