InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SERPINE1

Summary

InnateDB Protein

IDBP-692675.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINE1

Protein Name

Plasminogen activator inhibitor 1

Synonyms

PAI1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019232

InnateDB Gene

IDBG-640415 (SERPINE1)

Protein Structure

UniProt Annotation

Function

Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Vascular endothelial cells may be the primary site of synthesis of plasma PAI1.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0001300	chronological cell aging
GO:0001525	angiogenesis
GO:0010466	negative regulation of peptidase activity
GO:0010469	regulation of receptor activity
GO:0010757	negative regulation of plasminogen activation
GO:0010951	negative regulation of endopeptidase activity
GO:0014912	negative regulation of smooth muscle cell migration
GO:0030162	regulation of proteolysis
GO:0030194	positive regulation of blood coagulation
GO:0030336	negative regulation of cell migration
GO:0032757	positive regulation of interleukin-8 production
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0035491	positive regulation of leukotriene production involved in inflammatory response
GO:0042127	regulation of cell proliferation
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0050729	positive regulation of inflammatory response
GO:0050829	defense response to Gram-negative bacterium
GO:0051918	negative regulation of fibrinolysis
GO:0061044	negative regulation of vascular wound healing
GO:0071222	cellular response to lipopolysaccharide
GO:0090026	positive regulation of monocyte chemotaxis
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098	negative regulation of smooth muscle cell-matrix adhesion
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR023796 Serpin domain

PFAM

PF00079

PRINTS

PIRSF

SMART

SM00093

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13909

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281375

UniGene

Bt.5229

RefSeq

NP_776562

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103451 BT025406 X16383 X52906

GenPept

AAI03452 ABF57362 CAA34419 CAA37094