InnateDB Protein
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IDBP-692710.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TRIP6
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Protein Name
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Thyroid receptor-interacting protein 6
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000001503
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InnateDB Gene
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IDBG-640448 (TRIP6)
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Protein Structure
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Function |
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
76 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q3SX26
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
615869
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UniGene |
Bt.35776
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RefSeq |
NP_001030546
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC104544
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GenPept |
AAI04545
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