Version 5.4
Bos taurus Protein: AP4M1
Summary
InnateDB Protein IDBP-693001.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP4M1
Protein Name AP-4 complex subunit mu-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003736
InnateDB Gene IDBG-640709 (AP4M1)
Protein Structure
UniProt Annotation
Function Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal- lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus, trans-Golgi network {ECO:0000250}. Membrane, coated pit {ECO:0000250}. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006895 Golgi to endosome transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005905 coated pit
GO:0016020 membrane
GO:0030131 clathrin adaptor complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001392 Clathrin adaptor, mu subunit
IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR011012 Longin-like domain
IPR022775 AP complex, mu/sigma subunit
IPR028565 Mu homology domain
PFAM PF00928
PF01217
PRINTS PR00314
PIRSF PIRSF005992
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q29RY8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 768040
UniGene Bt.59228
RefSeq NP_001070567
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113334
GenPept AAI13335

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca