InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SMAP2

Summary

InnateDB Protein

IDBP-693024.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAP2

Protein Name

Stromal membrane-associated protein 2

Synonyms

SMAP1L;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000029227

InnateDB Gene

IDBG-640732 (SMAP2)

Protein Structure

UniProt Annotation

Function

GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001164 Arf GTPase activating protein

PFAM

PF01412

PRINTS

PR00405

PIRSF

SMART

SM00105

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5EA00

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

514465

UniGene

Bt.89350

RefSeq

NP_001069138

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123771 BT020769

GenPept

AAI23772 AAX08786