Version 5.4
Bos taurus Protein: PPP3CA
Summary
InnateDB Protein IDBP-693201.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP3CA
Protein Name Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000047848
InnateDB Gene IDBG-640885 (PPP3CA)
Protein Structure
UniProt Annotation
Function Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1 (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005516 calmodulin binding
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0051592 response to calcium ion
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042383 sarcolemma
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS PR00114
PIRSF
SMART SM00156
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48452
PhosphoSite PhosphoSite-
TrEMBL A9ZTJ7
UniProt Splice Variant
Entrez Gene 286852
UniGene Bt.3966
RefSeq XP_005207750
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB375792 BC123668 DQ231569 U33868
GenPept AAC48473 AAI23669 ABB22788 BAF99030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca