Version 5.4
Bos taurus Protein: EIF4E
Summary
InnateDB Protein IDBP-693276.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4E
Protein Name Eukaryotic translation initiation factor 4E
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012530
InnateDB Gene IDBG-640970 (EIF4E)
Protein Structure
UniProt Annotation
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, P-body {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0045931 positive regulation of mitotic cell cycle
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0005845 mRNA cap binding complex
GO:0010494 cytoplasmic stress granule
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0016442 RISC complex
GO:0033391 chromatoid body
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001040 Translation Initiation factor eIF- 4e
IPR023398 Translation Initiation factor eIF- 4e-like domain
PFAM PF01652
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9N0T5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281751
UniGene Bt.97370
RefSeq NP_776735
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF257235 BC111272
GenPept AAF66991 AAI11273

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca