Version 5.4
Bos taurus Protein: AIMP2
Summary
InnateDB Protein IDBP-693284.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIMP2
Protein Name Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Synonyms JTV1;
Species Bos taurus
Ensembl Protein ENSBTAP00000009687
InnateDB Gene IDBG-640978 (AIMP2)
Protein Structure
UniProt Annotation
Function Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0006915 apoptotic process
GO:0007275 multicellular organismal development
GO:0008285 negative regulation of cell proliferation
GO:0030154 cell differentiation
GO:0031398 positive regulation of protein ubiquitination
GO:0060510 Type II pneumocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
PFAM PF00043
PF14497
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0II26
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 520979
UniGene
RefSeq NP_001069281
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122837
GenPept AAI22838

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca