Version 5.4
Bos taurus Protein: CDC27
Summary
InnateDB Protein IDBP-693741.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC27
Protein Name Cell division cycle protein 27 homolog
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003533
InnateDB Gene IDBG-641367 (CDC27)
Protein Structure
UniProt Annotation
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.
Predicted by orthology
Total 95 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005876 spindle microtubule
Protein Structure and Domains
PDB ID
InterPro IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat
PFAM PF00515
PF07719
PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7Z061
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540660
UniGene Bt.65174
RefSeq NP_001098898
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC153259
GenPept AAI53260

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca