InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TRAF2

Summary

InnateDB Protein

IDBP-693833.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF2

Protein Name

TNF receptor-associated factor 2

Synonyms

TANK;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013869

InnateDB Gene

IDBG-641438 (TRAF2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 264 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	264 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005174	CD40 receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding
GO:0042802	identical protein binding
GO:0046625	sphingolipid binding
GO:0046872	metal ion binding

Biological Process

GO:0002726	positive regulation of T cell cytokine production
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0030163	protein catabolic process
GO:0032743	positive regulation of interleukin-2 production
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0043623	cellular protein complex assembly
GO:0046328	regulation of JNK cascade
GO:0051023	regulation of immunoglobulin secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:0070207	protein homotrimerization
GO:0070534	protein K63-linked ubiquitination
GO:0071732	cellular response to nitric oxide
GO:0090073	positive regulation of protein homodimerization activity
GO:0097300	programmed necrotic cell death
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR001293 Zinc finger, TRAF-type
IPR001841 Zinc finger, RING-type
IPR002083 MATH
IPR008974 TRAF-like
IPR012227 TNF receptor-associated factor TRAF
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF00917
PF00097

PRINTS

PIRSF

PIRSF015614

SMART

SM00184
SM00061

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt